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Researchers Struggling To Know Why Covid-19 Spreads Quickly in Patients’ Lungs

Overview:
Researchers are struggling to discover the reason behind the spread of the pandemic situation created by a novel coronavirus, specifically its severe outset among patients suffering from lung diseases. Here in this article, we’ll get to know insight into the increasing number of cases suffering from this disease and some latest updates and ongoing research findings.

Summary:

  • Researchers are continually struggling to find out the preventive measures of Coronavirus disease to escape its symptoms.
  • The ongoing research is focused on the active participation and spread of the coronavirus in patients already suffering from lungs disorder.
  • The research findings revolve around the response of the immune system with nerves in the lungs.
  • The patients suffering from Acute Respiratory Distress Syndrome (ARDS) are at a higher risk of getting severely ill by the attack of Covid-19.

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An Ongoing Global Research on Covid-19 in Relation With Patients Suffering from Lungs Disorder:
Researchers are continually struggling to escape the symptoms of Covid-19. But these symptoms spread very quickly in the case of patients suffering from lung disorders. According to the latest research at Texas University, the number of Covid-19 cases has increased to 9 million in total.
Lung inflammation occurs as a result of getting severely attacked by Covid-19 in patients already suffering from cardiovascular or lung diseases. It becomes a reason for the fast and increased deterioration of the lungs. The ongoing research findings suggest that this process results in response to neurogenic swelling that involves the inflammation of nerves surrounding the lungs region.

The Role of the Immune System and Cytokine Storm Induction:
The situation of patients suffering from Covid-19 gets critical in the case of Acute Respiratory Distress Syndrome (ARDS). These patients are unable to breathe properly, and the saturation rate of the blood decreases, making their condition worse, and in some cases, it ultimately leads to their death.

An image demonstrating neurogenic inflammation of the lungs

Patients suffering from ARDS often suffer from Cytokine storms as a result of the Covid-19 attack. In the case of the cytokine storm, the body starts to produce signals as a result of the formation of signaling proteins responsible for activating the immune system. The cells of the immune system, in turn, enable the signaling of sensory neurons in the body that leads to behavioral changes in humans.
When integrated with our immune cells, these sensory neurons have a significant impact on controlling the response initiated by our immune system. In the same manner, pathogens also interact with sensory neurons to start colonization and survival.

Working of Functional Proteins or Receptors:
A comparative analysis of molecular profiling of dorsal neuronal cell bodies and immune cells from Covid-19 patient’s lungs was conducted. The research findings suggest that merging these two profiles has provided us a detailed understanding and an in-depth analysis of the mechanism between nerve cells and immune cells.
As mentioned earlier, the outset of abundant signaling proteins in response to the Covid-19 attack is at a higher rate in already existing lung patients. In the same manner, there is a sharp increase in the production of a receptor of immune cells known as NMDA (N-methyl D-aspartate). The increased production of this receptor results in bridging the communication gap between immune cells through glutamate. The research analysis suggests that we can reduce the damaging effect produced by the pathogenic cells by interrupting this action. There are already developed antagonists for NMDA receptors, which can help in blocking the targeted location.

Flow chart of NMDA receptor against COVID

Scientific Progress & Covid-19:
The ongoing research on Covid-19 is happening at a faster rate today. The research findings have helped us evaluate the relationship between immune cells and sensory neurons. The study of its in-depth relationship will help us target the pathogen or virus at a specific position and block its function by suppressing its key proteins. These results or research findings will prove beneficial as the latest development and create a major influence in the field of medical sciences.

Follow our blog section to learn more about the latest developments in medical sciences during this pandemic situation created by Covid-19.

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